The story of Wit is the story of Vivien Bearing, a professor of English who has spent years researching and teaching the metaphysical sonnets of John Donne and, while doing so, has felt that she had absolute control over her life and work. Then she is diagnosed with aggressive, ovarian cancer, becomes a patient in an experimental cancer research unit and finds that she has to reassess everything. Vivien initially observes what is happening to her with anger and amazement but also at times with an amused detachment. Gradually, however, the protective coatings with which she has surrounded herself are stripped away as she journeys towards her inevitable end.